Skin bio-remodelling has become one of the cornerstones of modern aesthetic practice. Among the wide range of injectables available, two names consistently come up in practitioner conversations: Profhilo and Sunekos. Both promise improved skin quality through biostimulation rather than simple volumization, yet their formulations, mechanisms of action, and clinical applications are fundamentally different.
This guide breaks down the science behind each product, their indications, and how to decide which one fits your patient's needs, so you can make an informed choice for your next order.
What Is Profhilo?
Profhilo is an injectable developed by IBSA using patented NAHYCO Hybrid Technology. Unlike traditional dermal fillers, it stabilizes high and low molecular weight hyaluronic acid through a thermal process, without relying on chemical cross-linking agents such as BDDE.
Each 2ml syringe contains one of the highest concentrations of hyaluronic acid available on the aesthetic market: 32mg of high molecular weight HA combined with 32mg of low molecular weight HA, for a total of 64mg per syringe. This unique hybrid cooperative complex allows the product to spread evenly through the tissue while triggering a genuine bio-remodelling response.
How Profhilo Works
Once injected, Profhilo interacts directly with skin receptors to stimulate the production of collagen types I and III, as well as elastin and adipocyte stem cells. Rather than physically filling wrinkles, it works at a cellular level to restore the skin's underlying structure and hydration from within. The slow-release mechanism of the hybrid complex means the bio-remodelling process continues for several weeks after injection, with full results typically visible around four weeks post-treatment.
Profhilo Structura
For patients with deeper structural changes, IBSA also developed Profhilo Structura, a more cohesive formulation containing 45mg of high molecular weight HA and 45mg of low molecular weight HA per 2ml syringe. While standard Profhilo focuses primarily on bio-remodelling and hydration, Structura is specifically indicated for facial volume restoration in areas affected by adipose tissue depletion, offering a lifting effect comparable to cross-linked fillers while maintaining a strong safety profile.
What Is Sunekos?
Sunekos takes a different biochemical approach. Developed by Professional Dietetics, it combines non-cross-linked hyaluronic acid with a patented complex of six amino acids: glycine, L-proline, L-lysine, L-leucine, L-valine, and L-alanine, known as the HY6AA formula.
The product line includes two main formulations: Sunekos Performa, which contains low molecular weight hyaluronic acid (200 kDa), and Sunekos 1200, which uses a higher molecular weight hyaluronic acid (1200 kDa). Both are designed to be used together or sequentially depending on the treatment protocol, following the High Performance Technique developed by the brand.
How Sunekos Works
The amino acids in Sunekos act as direct building blocks for collagen and elastin synthesis, while the hyaluronic acid component supports hydration and acts as a delivery vehicle. Together, they stimulate fibroblasts to regenerate the extracellular matrix, promoting natural production of collagen types I, III, IV, and VII. This mechanism makes Sunekos particularly effective for restoring the skin's underlying scaffold rather than simply adding volume or hydration.
Sunekos Performa is generally positioned as a maintenance treatment for early signs of ageing, while Sunekos 1200 is used for more intensive renewal, particularly in cases of pronounced skin laxity or photoaging.
Profhilo vs Sunekos: Key Differences
| Profhilo | Sunekos | |
|---|---|---|
| Active ingredients | Hyaluronic acid only (H-HA + L-HA) | Hyaluronic acid + 6 amino acids |
| Technology | NAHYCO Hybrid Technology | HY6AA Formula |
| HA concentration | 64mg/2ml (32+32) | Lower HA concentration, amino acid-driven |
| Primary mechanism | Bio-remodelling via HA hybrid complex | ECM regeneration via amino acid stimulation |
| Best suited for | Skin laxity, overall firmness, hydration | Early ageing signs, fine lines, ECM quality |
| Typical protocol | 2 sessions, 4 weeks apart | 3-4 sessions, 7-15 days apart |
| Areas of application | Face, neck, hands, décolleté, body | Face, neck, eye area, décolleté, hands, body |
Which One Should You Choose?
The choice between Profhilo and Sunekos ultimately depends on the patient's skin condition and treatment goals.
Profhilo is generally the preferred option for patients presenting with more advanced skin laxity who need a strong hydration and firming effect. Its high HA concentration and scaffold effect make it particularly effective for the lower face, neck, and jawline, where skin tends to lose elasticity with age.
Sunekos tends to perform best on patients in the earlier stages of skin ageing, particularly around delicate areas such as the under-eye region, where its amino acid-driven approach allows for a gentler, more gradual improvement in skin quality without the higher HA load found in Profhilo.
In practice, many clinics use both products as complementary tools, choosing one or the other depending on the treatment area, the patient's age, and the specific skin concern being addressed. Some practitioners also alternate between the two products across treatment cycles to maximize results.
A Note on Safety and Sourcing
Both Profhilo and Sunekos are CE-certified medical devices that should only be administered by licensed medical professionals. As with any injectable, sourcing from authorized distributors is essential to guarantee product authenticity, traceability, and patient safety.
At Hyashop, we supply both Profhilo and Sunekos (Performa and 1200) directly from authorized channels, with CE certification and express delivery across Europe and internationally.
This article is intended for licensed healthcare professionals and aesthetic practitioners. Medical devices should only be administered by qualified physicians. Hyashop accepts no responsibility for the incorrect or unprofessional use of its products.
